From the Colosseum to Trastevere, the treasures of the Vatican and Villa Borghese, discover the best things to do in Rome in 2 days.
I’ve visited Rome many times and each time it never fails to amaze me. The magic of this city lies in the warmth of its people, the beauty of its monuments, and the fact that wherever you turn, you’ll stumble upon a breathtaking ruin or historic site. There’s so much to see that even a month wouldn’t be enough to explore it all!
That’s why I decided to write this essential itinerary—perfect for those who only have a weekend and have never visited the city before. Each day’s route can be done entirely on foot, but I’ve included some tips in case you prefer to use public transport.
Check out the schedule for both days below and save the maps to see exactly where each stop is.
Day 1: From the Colosseum to Trastevere
For your first day in the city, I’ve planned an itinerary that includes some of the most famous attractions and hotspots, so you can explore the history of Ancient Rome and immerse yourself in the city’s lively culture.
10am – Start your day at the Colosseum
Estimated visit time: 1–2 hours
Metro stop: Colosseo (Line B/B1, about 6 min. on foot)
What better way to begin exploring Rome than with its most iconic monument: the Colosseum. Inaugurated in 80 AD, this massive amphitheater could hold up to 87,000 spectators, who came here to enjoy all kinds of shows—from gladiator battles to mythological dramas.
Besides admiring it from the outside, I recommend spending one to two hours visiting the interior. You’ll be able to see the arena, the stands and the underground chambers. To avoid long ticket queues, book your Colosseum tickets online.
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Midday – Explore the ruins of the Roman Forum
Estimated visit time: 1 hour
Metro stop: Colosseo (Line B/B1, about 6 min. on foot)
Entrance: 1 min. on foot from the Colosseum
The perfect follow-up to your discovery of Ancient Rome is a visit to the Roman Forum. This archaeological area preserves the remains of buildings that were central to social, economic, religious and political life during the Empire. Walking among the ruins, you’ll see the remains of majestic temples, such as the Temple of Saturn and Temple of Vesta, the Basilica of Maxentius, the Arch of Titus and the Via Sacra.
Tip: Book a guided tour of the Colosseum and Roman Forum led by an archaeologist. It will help you fully appreciate the importance of these sites and uncover the fascinating history of this ancient civilization.
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1:30pm – Enjoy lunch in the heart of Rome
Finding a good place to eat near the Colosseum that isn’t a tourist trap can be tricky. That’s why I’ve rounded up four great spots nearby that won’t disappoint.
Recommended restaurants near the Colosseum:
- Osteria Angelino dal 1899 (6 min. on foot): A traditional restaurant where you can enjoy carbonara, carciofi alla giudia (Jewish-style artichokes), cacio e pepe (a cheese and pepper pasta dish), saltimbocca (veal wrapped in prosciutto and sage) and many other local dishes.
- Lelé Natural Food (9 min. on foot): A casual bistro with local products, it’s perfect for those looking for vegetarian-friendly options.
- Li Rioni (10 min. on foot): Here, you can enjoy Roman-style pizza—thin, crispy and absolutely delicious.
- La Prezzemolina (3 min. on foot): An ideal spot for a quick and tasty lunch of pizza al taglio (by the slice), whole pizzas, supplì (fried rice balls) and other baked goods.
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3pm – Admire Piazza Venezia and the Vittoriano
Walking distance from the Colosseum and Roman Forum: About 5 minutes
At Piazza Venezia you’ll start to experience the vastness of Rome—and also a bit of its chaotic spirit. Here, you’ll see the Vittoriano, also known as the Altar of the Fatherland, a national monument celebrating the unification of Italy and the Risorgimento. You can admire its majestic architecture, the equestrian statue of King Vittorio Emanuele II, and the historic Palazzo Venezia.
If you have extra time, consider visiting Palazzo Venezia, which features lavish interiors and a museum dedicated to the Renaissance.
4pm – Discover the treasures of the historic center
Total walking time: 22 minutes from Piazza Venezia
Public transport to the Pantheon: Bus 85, 51, 87, 81, 160
A short walk from Piazza Venezia will take you to some of Rome’s most stunning squares and monuments. In just over ten minutes, you’ll arrive at the Pantheon—a temple originally dedicated to all gods, and a true architectural masterpiece with its massive dome and fascinating central oculus. A visit takes about 30 minutes and is a truly memorable experience.
Next, head to Piazza Navona, one of the most elegant squares in Rome. Built in Baroque style it features three beautiful fountains, including the famous Fountain of the Four Rivers by Bernini. I enjoyed the square’s lively atmosphere while cooling off with a delicious gelato.
The final stop of this walk is Campo de’ Fiori, a vibrant square full of local charm, which is also home to a famous morning food market. The statue of Giordano Bruno stands at its center, while all around it are bars and cozy spots perfect for grabbing a drink. Drunken Ship is a fun choice if you’re in the mood for a beer outside.
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7pm – Watch the sunset from the Orange Garden
Estimated visit time: 1 hour
Public transport: Bus 628, 81, 160, or 83
During my last trip to Rome, I decided to watch the sunset from one of my favorite spots—the Orange Garden (Giardino degli Aranci). This beautiful, symmetrical garden sits on the Aventine Hill, offering a romantic view over St Peter’s Basilica and the city center.
But did you know that St Peter’s Basilica can also be admired from another unique perspective? Near the garden, you’ll find the famous keyhole of the Knights of Malta gate. Peeking through it, you’ll see St Peter’s dome perfectly framed by a tunnel of hedges. It’s not a hidden secret, so you may have to wait in line, but it is truly magical.
Tip: A great way to explore this and other iconic spots at sunset (or at any time) is by booking a private golf cart tour. It’s a fun experience, where for about 2.5 hours, you’ll feel like you’re in the movie Roman Holiday.
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Relish a Roman dinner in Trastevere
Public transport: 8BUS or tram 8
There’s no better way to immerse yourself in Roman cuisine and its evening atmosphere than by heading to Trastevere. This picturesque neighborhood is the perfect place for a scenic stroll and a taste of Rome’s traditional dishes.
Recommended restaurants & bars in Trastevere:
- Tonnarello: Generous portions of homemade pasta at very affordable prices.
- Nannarella: A lively, informal spot for enjoying carbonara, cacio e pepe (cheese and pepper pasta), amatriciana, abbacchio (roasted lamb), and many more local dishes.
- Antica Osteria Rugantino: A no-frills osteria where you can ‘fare caciara’ (get noisy and rowdy) while digging into great food and house wine.
- Freni e Frizioni (cocktail bar): Serving great cocktails, this popular terrace bar is perfect for aperitivo.
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Day 2: Vatican treasures, Baroque splendor and urban oases
Your second day in Rome features more iconic landmarks, from the Vatican to Piazza di Spagna, before ending with a sunset at Villa Borghese.
8am – Visit the Vatican Museums and the Sistine Chapel
Estimated visit time: 3 hours
Metro stop: Ottaviano (Line A, about 8 min. on foot)
For your second day, I suggest waking up early to make the most of your visit to the Vatican Museums. This museum is a must-see, not only for its immense art collection but also for the incredible atmosphere.
Of course, your visit also includes the world-famous Sistine Chapel. Michelangelo’s grand frescoes are nothing short of breathtaking, and the recent conclave makes this place feel even more special.
Good to know: On the last Sunday of each month, entrance is free and you can book online. But keep in mind it might be more crowded than usual.
Tip: Book a small group tour for a more relaxed experience and to get insightful explanations from an expert guide.
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11am – Admire St Peter’s Basilica and climb the dome
Estimated visit time: 1 hour
Metro stop: Ottaviano (Line A, about 13 min. on foot)
Walking distance from the Vatican Museums: 13 minutes
After the museums, gather your energy and head to St Peter’s Basilica. This church is not only the second largest in the world, it’s also an architectural masterpiece. Don’t miss Bernini’s baldachin and Michelangelo’s Pietà, located right at the entrance. And remember to look up at the basilica’s massive dome and its vibrant mosaics.
If you have time, climb to the top of the dome. From ‘Er Cupolone’, the panoramic view of Rome is well worth the effort!
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Dig into lunch in Borgo Pio
Metro stop: Ottaviano (Line A, about 10 min. on foot)
Walking distance from St Peter’s Basilica: 5 minutes
In this part of the city, Borgo Pio is one of my favorite spots for a great lunch. Here, you’ll find authentic trattorias and beautiful terraces, away from the hustle and bustle of St Peter’s Square.
Recommended restaurants in Borgo Pio:
- Borghiciana Pastificio Artigianale: A cozy trattoria with delicious carbonara and lasagna (it’s worth it, even if you have to wait for a seat)
- Da Romolo alla Mole Adriana: Pasta, pizza and excellent main courses— there’s something for everyone.
- Mordi Sandwichouse® – Borgo Pio 139: Perfect for a quick lunch. Here you’ll enjoy panini and pizza bianca (literally ‘white pizza’, meaning without tomatoes). Don’t miss the porchetta sandwich.
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2pm – Walk to Castel Sant’Angelo and Ponte degli Angeli
Estimated visit time: 45 minutes
Walking distance from Borgo Pio: 10 minutes
After lunch head toward the Tiber River, where you can admire the Castel Sant’Angelo. It’s worth a stop, even if you just want to look at it from the outside. Take the time to marvel at the beautiful Ponte degli Angeli, adorned with stunning Baroque statues.
Not your first time in Rome? Maybe you want to dig deeper and uncover the Vatican’s secrets and scandals. Join this fascinating 2.5-hour tour about Rome’s hidden history.
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3pm – Climb the Spanish Steps and toss a coin in the Trevi Fountain
Estimated visit time: 1.5 hours
Metro stop: Spagna (Line A, about 2 min. on foot)
Walking distance from Ponte degli Angeli: 22 minutes
Continue your journey to Piazza di Spagna, where you’ll find the famous Spanish Steps. It’s the perfect spot to take a short break and blend in with the locals.
A 10-minute walk will take you to Rome’s iconic Trevi Fountain. Head down a narrow street which will suddenly open onto the grand fountain; it almost seems too big for the square it sits in. I must admit, despite being very touristy, it’s absolutely unforgettable.
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6pm – Unwind at Villa Borghese and watch the sunset at Piazza del Popolo
Estimated visit time: 1.5 hours
Public transport: Bus 61, 89, 160, 490
Walking distance from Trevi Fountain: 20 minutes
End your busy day with a relaxing walk through Villa Borghese, Rome’s green lung. This city oasis is perfect for slowing down and catching your breath. Follow the paths to a scenic viewpoint above Piazza del Popolo, where the view is magnificent, especially at sunset when the city glows in golden hues.
Still in the mood for art? The Borghese Gallery is truly breathtaking, featuring masterpieces by Caravaggio, Bernini, Titian and more. Reservations are required.
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Finish with dinner in Prati or Piazza del Popolo
Metro stops: Lepanto & Flaminio (Line A, 5-10 min. on foot)
To make your final dinner one to remember, head to an elegant restaurant in Prati or Piazza del Popolo. This area offers a great mix of modern and classic Roman cuisine. It’s the perfect way to wrap up your trip, with a glass of good wine and a hearty plate of pasta.
Recommended restaurants in Prati & Piazza del Popolo:
- Babette: A Franco-Italian restaurant with a beautiful terrace.
- Alla Rampa dei Gracchi: Authentic Roman flavors and grilled meats.
- AMALFI MADRE: Excellent pasta dishes and Neapolitan pizzas.
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